Mr. Brooks is a successful businessman, a generous philanthropist, a loving father, and a devoted husband. He is seemingly perfect, but he has a secret. He is also the notorious Thumbprint Killer, and no one has ever suspected it until now. Tracy Atwood is a tough detective whose devotion to her craft catches the attention and respect of the serial killer she is hunting, which leads to a symbiotic relationship.

Senior Charley Brewster finally has it all. He's running with the cool kids and dating the hottest girl in high school. But all hell breaks loose when charming Jerry Dandrige moves in next door. Charlie thinks there's something odd about him, although no one, including his mom seems to notice. But after too many of his classmates vanish under bizarre circumstances, Charley comes to an unmistakable conclusion: Jerry is a vampire preying on his neighborhood!...

Although he has been missing for several years and the entire town thinks her father has abandoned her family, Meg steadfastly believes the best and protects her younger brother, Charles Wallace, from the brunt of the rumors and taunting. It is he, however, who convinces her to join him, the school sports star Calvin, and three unusual women on an interplanetary voyage to rescue their father from a vast evil.