At the age of forty, Billy Baker discovers that he's lost something crucial along the way: his friends. Other priorities always seemed to come first, until all his close friendships had lapsed into distant memories. When he takes an assignment to write an article about the modern loneliness epidemic, he realizes just how common it is to be a middle-aged loner: almost fifty million Americans over the age of forty-five, especially men, suffer from chronic loneliness, which the surgeon general has declared one of the nation's "greatest pathologies," worse than smoking, obesity, or heart disease in increasing a person's risk for premature death. Determined to defy these odds, Baker vows to salvage his lost friendships and blaze a path for men (and women) everywhere to improve their relationships old and new.

A middle-aged everyman who realizes that he doesn't have any close friends is inspired to set out on a humorous and ultimately moving quest to revive old tribes and build new ones, all with the goal of having someone to hang out with on Wednesday nights.