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Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.

Life in the emergency room at San Antonio Memorial is never routine, and the men and women that make up the night shift team are a special breed. The new season finds the crew still recovering from a shocking hostage situation that left one of their colleagues dead. The experience brought them all a little closer but also exposed some personal weaknesses.

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.

Sam Griffith is a gifted heart surgeon who excels in her new leadership role as chief of surgery after her renowned boss falls into a coma. When her former boss wakes up months later demanding to resume his duties, Sam is tasked with supervising this egotistical expert with a scalpel who never acknowledged her stellar talent. Complicating matters, the caustic and arrogant Dr. Rob 'Griff' Griffith also happens to be her father. As Griff defies Sam's...

A big-city doctor on the way to a job interview in L.A. gets stranded in a small town in forced to do community service in the way of medical work. Although eager to leave, a local beauty might persuade him to stay.

A plastic surgeon who is romancing a much younger schoolteacher enlists his loyal assistant to pretend to be his soon-to-be ex-wife in order to cover up a careless lie. When more lies backfire, the assistant's kids become involved, and everyone heads off for a weekend in Hawaii that will change all their lives.